Desktop Hardware and Support

Should I shut down Time Machine before a Retrospect backup or vice versa?

Yes. Exclude each from the other's backup.

Make sure to exclude your external Time Machine volume from Retrospect lest it continuously try to back up that data. Likewise, don't have your Retrospect backup archive going onto an attached volume that Time Machine sees and wants to back up.

Help! I did not back up my encryption keys or there is a problem with my backup.

If you did not back up your keys, or if there is a problem with your back up, your Data Recovery Agent (DRA) can still recover your files. Submit a HelpSU request for assistance. If you have permitted other users to share your encrypted files, those users can recover your data as well.